Experimental and Molecular Pathology

Experimental and Molecular Pathology

Xanthohumol suppresses inflammatory response to warm ischemia–reperfusion
induced liver injury

Christoph Dorn, Sabine Massinger, Andreas Wuzik, Jörg Heilmann, Claus Hellerbrand

Hepatic ischemia/reperfusion (I/R) injury occurs in a variety of clinical scenarios, including transplantation, liver resection, trauma, and hypovolemic shock. The molecular mechanisms causing liver injury after I/R have been subject of several studies, which revealed a series of complex interactions of various participant inflammatory pathways (Walsh et al., 2009; Zwacka et al., 1998a). The process of hepatic I/R-injury can be divided into two phases; an acute phase (the first 6 h after reperfusion) and the following subacute phase (Fan et al., 1999). The acute phase is characterized by acute generation of reactive oxygen species (ROS) subsequent to reoxygenation of the liver leading to marked hepatocellular damage, measurable by an increase of serum alanine transaminase levels peaking 3 to 6 h after reperfusion (Parks and Granger, 1988; Rauen et al., 1994). The secondary subacute phase is associated with …

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